Journal: NPJ Parkinson's Disease
Article Title: Vagus nerve stimulation in Parkinson’s disease: a scoping review of animal studies and human subjects research
doi: 10.1038/s41531-024-00803-1
Figure Lengend Snippet: Vagus nerve stimulation (VNS), including transauricular VNS (taVNS), cervical VNS (cVNS) and invasive VNS (iVNS), enables bottom-up modulation of higher brain areas by influencing vagal nuclei in the brainstem. The schematic illustration shows brain circuits and general concepts involved in the bottom-up regulation of neural networks implicated in PD pathology, including the locus coeruleus (LC), which projects various parts of the brain including the substantia nigra pars compacta (SNpc) and striatum of the basal ganglia, the hippocampus, the amygdala, the thalamus, and the cerebellum. These brain areas ultimately influence activity in the motor cortex, producing successful movement patterns. The red x’s represent relevant brain areas and pathways that are affected by PD pathology. The green checkmark represents the hypothesized therapeutic target of VNS, with the figure demonstrating the spared connectivity to multiple other brain areas that influence motor control. STN. subthalamic nucleus, GP. globus pallidus. This figure does not encompass all of the neurophysiological complexities of PD and is meant to provide the reader with a general overview.
Article Snippet: Fig. 1 Photographs of various Vagus Nerve Stimulation Devices. a Implanted Vagus Nerve Stimulation Device by LivaNova.
Techniques: Activity Assay, Control